Hemopexin Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH23-09] (HA751887)

UNIPROT #

P02790

PROTEIN NAME

Hemopexin

SYNONYMS

Beta 1B glycoprotein antibody;Beta-1B-glycoprotein antibody;FLJ56652 antibody;HEMO antibody;HEMO_HUMAN antibody;Hemopexin antibody;Hpx antibody;HX antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Hemopexin (or haemopexin; Hpx; Hx), also known as beta-1B-glycoprotein, is a glycoprotein that in humans is encoded by the HPX gene and belongs to the hemopexin family of proteins. Hemopexin is the plasma protein with the highest binding affinity for heme. Hemoglobin itself circulating alone in the blood plasma (called free hemoglobin, as opposed to the hemoglobin situated in and circulating with the red blood cell.) will soon be oxidized into met-hemoglobin which then further disassociates into free heme along with globin chain. The free heme will then be oxidized into free met-heme and sooner or later the hemopexin will come to bind free met-heme together, forming a complex of met-heme and hemopexin, continuing their journey in the circulation until reaching a receptor, such as LRP1, on hepatocytes or macrophages within the spleen, liver and bone marrow. Hemopexin's arrival and subsequent binding to the free heme not only prevent heme's pro-oxidant and pro-inflammatory effects but also promotes free heme's detoxification. Hemopexin is different from haptoglobin, the latter always binds to free hemoglobin.