Granzyme B Recombinant Rabbit Monoclonal Antibody [PSH14-66] (HA723664)

UNIPROT #

P10144

PROTEIN NAME

Granzyme B

SYNONYMS

C11 antibody;Cathepsin G like 1 antibody;Cathepsin G-like 1 antibody;CCPI antibody;CGL 1 antibody;CGL1 antibody;CSP B antibody;CSPB antibody;CTLA 1 antibody;CTLA-1 antibody;CTLA1 antibody;CTSGL1 antibody;Cytotoxic serine protease B antibody;Cytotoxic T lymphocyte associated serine esterase 1 antibody;Cytotoxic T lymphocyte proteinase 2 antibody;Cytotoxic T-lymphocyte proteinase 2 antibody;Fragmentin 2 antibody;Fragmentin-2 antibody;GRAB_HUMAN antibody;Granzyme 2 antibody;Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody;Granzyme B antibody;Granzyme-2 antibody;GranzymeB antibody;GRB antibody;Gzmb antibody;Hlp antibody;Human lymphocyte protein antibody;Lymphocyte protease antibody;Protease, serine, B antibody;SECT antibody;T cell serine protease 1 3E antibody;T cell serine protease 1-3E antibody;T-cell serine protease 1-3E antibody

SUBCELLULAR LOCATION

Secreted, Cytolytic granule.

FUNCTION

Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells. Granzyme B has also been found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells. The secondary functions of granzyme B are also numerous. Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling. Elevated levels of granzyme B are also implicated in a number of autoimmune diseases, several skin diseases, and type 1 diabetes.