GM2A Rabbit Polyclonal Antibody (HA500560)

UNIPROT #

P17900

PROTEIN NAME

GM2A

SYNONYMS

Cerebroside sulfate activator protein antibody;ganglioside GM2 activator antibody;Ganglioside GM2 activator isoform short antibody;Ganglioside GM2 activator precursor antibody;GM2 activator antibody;GM2 AP antibody;GM2 ganglioside activator antibody;GM2 ganglioside activator protein antibody;GM2-AP antibody;GM2A antibody;GM2AP antibody;OTTHUMP00000160619 antibody;SAP 3 antibody;SAP-3 antibody;SAP3 antibody;SAP3_HUMAN antibody;Shingolipid activator protein 3 antibody;Sphingolipid activator protein 3 antibody

SUBCELLULAR LOCATION

Lysosome.

FUNCTION

GM2 ganglioside activator also known as GM2A is a protein which in humans is encoded by the GM2A gene. The protein encoded by this gene is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. It was identified as a member of ML domain family of proteins involved in innate immunity and lipid metabolism in the SMART database.