Glutamine Synthetase Mouse Monoclonal Antibody (IRS033)

UNIPROT #

P15104

PROTEIN NAME

Glutamine Synthetase

SYNONYMS

cell proliferation-inducing protein 59 antibody;Cgl2214 antibody;GLNA antibody;GLNA_HUMAN antibody;GLNS antibody;GLUL antibody;Glutamate ammonia ligase antibody;Glutamate decarboxylase antibody;Glutamate--ammonia ligase antibody;glutamine synthase antibody;Glutamine synthetase antibody;glutamine synthetase I antibody;GS antibody;PIG 43 antibody;PIG 59 antibody;PIG43 antibody;PIG59 antibody;Proliferation inducing protein 43 antibody

SUBCELLULAR LOCATION

Microsome, Cytosol, Mitochondrion, Cell membrane.

FUNCTION

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.