Glucose Transporter GLUT1 Recombinant Antibody [SA0377] - Rat IgG1 (Chimeric) (HA601521)

UNIPROT #

P11166

PROTEIN NAME

Glucose Transporter GLUT1

SYNONYMS

Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody;CSE antibody;DYT17 antibody;DYT18 antibody;DYT9 antibody;EIG12 antibody;erythrocyte/brain antibody;Erythrocyte/hepatoma glucose transporter antibody;facilitated glucose transporter member 1 antibody;Glucose transporter 1 antibody;Glucose transporter type 1 antibody;Glucose transporter type 1, erythrocyte/brain antibody;GLUT antibody;GLUT-1 antibody;GLUT1 antibody;GLUT1DS antibody;GLUTB antibody;GT1 antibody;GTG1 antibody;Gtg3 antibody;GTR1_HUMAN antibody;HepG2 glucose transporter antibody;HTLVR antibody;Human T cell leukemia virus (I and II) receptor antibody;MGC141895 antibody;MGC141896 antibody;PED antibody;RATGTG1 antibody;Receptor for HTLV 1 and HTLV 2 antibody;SLC2A1 antibody;Solute carrier family 2 (facilitated glucose transporter), member 1 antibody;Solute carrier family 2 antibody;Solute carrier family 2, facilitated glucose transporter member 1 antibody

SUBCELLULAR LOCATION

Cell membrane, Melanosome

FUNCTION

Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. One good source of GLUT1 is erythrocyte membranes. GLUT1 accounts for 2 percent of the protein in the plasma membrane of erythrocytes. GLUT1, found in the plasma membrane of erythrocytes, is a classic example of a uniporter. After glucose is transported into the erythrocyte, it is rapidly phosphorylated, forming glucose-6-phosphate, which cannot leave the cell. Mutations in this gene can cause GLUT1 deficiency syndrome 1, GLUT1 deficiency syndrome 2, idiopathic generalized epilepsy 12, dystonia 9, and stomatin-deficient cryohydrocytosis.