Gasdermin D (N terminal) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PD00-18] (HA750486)

UNIPROT #

P57764

PROTEIN NAME

Gasdermin D (N terminal)

SYNONYMS

1810036L03Rik antibody;DF 5L antibody;DF5L antibody;DFNA 5L antibody;DFNA5L antibody;FKSG 10 antibody;FKSG10 antibody;FLJ12150 antibody;Gasdermin antibody;Gasdermin D antibody;Gasdermin domain containing 1 antibody;Gasdermin domain containing protein 1 antibody;Gasdermin domain-containing protein 1 antibody;Gasdermin-D antibody;GasderminD antibody;GSDMD antibody;GSDMD_HUMAN antibody;GSDMDC 1 antibody;GSDMDC1 antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis . Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity.