Gankyrin Recombinant Rabbit Monoclonal Antibody [PSH17-80] (HA723949)

UNIPROT #

O75832

PROTEIN NAME

Gankyrin

SYNONYMS

26S proteasome non-ATPase regulatory subunit 10 antibody;26S proteasome regulatory subunit p28 antibody;Ankyrin repeat protein antibody;dJ889N15.2 antibody;Gankyrin antibody;Hepatocellular carcinoma-associated protein p28 II antibody;p28 antibody;p28(GANK) antibody;Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody;Proteasome 26S S10 antibody;PSD10_HUMAN antibody;Psmd10 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka et al.; Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, both transcription factors involved in tumor suppression and found mutated in many cancers. Gankyrin also has an anti-apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma.