GAD67 Recombinant Antibody [PSH08-30] - Guinea pig IgG2 (Chimeric) - BSA and Azide free (HA610408)

UNIPROT #

Q99259

PROTEIN NAME

GAD67

SYNONYMS

67 kDa glutamic acid decarboxylase antibody;CPSQ1 antibody;DCE1 antibody;DCE1_HUMAN antibody;EC 4.1.1.15 antibody;FLJ45882 antibody;GAD 67 antibody;GAD antibody;GAD-67 antibody;GAD1 antibody;Glutamate decarboxylase 1 (brain, 67kDa) antibody;Glutamate decarboxylase 1 antibody;Glutamate decarboxylase 1 brain 67kD antibody;Glutamate decarboxylase 1 brain 67kDa antibody;Glutamate decarboxylase 67 kDa isoform antibody;Glutamate decarboxylase, brain, 67-KD antibody;OTTHUMP00000041055 antibody;SCP antibody

SUBCELLULAR LOCATION

Cytoplasm, Plasma Membrane.

FUNCTION

There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.