FPR2 Rabbit Polyclonal Antibody (R1511-25)

UNIPROT #

P25090

PROTEIN NAME

FPR2

SYNONYMS

ALXR antibody;FMLP-R-I antibody;FMLP-R-II antibody;FMLP-related receptor I antibody;FMLPX antibody;Formyl peptide receptor 2 antibody;Formyl peptide receptor related antibody;Formyl peptide receptor-like 1 antibody;FPR2 antibody;FPR2_HUMAN antibody;FPR2A antibody;FPRH1 antibody;FPRH2 antibody;FPRL1 antibody;HM63 antibody;Lipoxin A4 receptor antibody;LXA4 receptor antibody;LXA4R antibody;N-formyl peptide receptor 2 antibody;RFP antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4). Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. The FPR2 receptor is expressed on human neutrophils, eosinophils, monocytes, macrophages, T cells, synovial fibroblasts, and intestinal and airway epithelium.