FITC Conjugated Human CD38 Recombinant Rabbit Monoclonal Antibody [SN07-20] (HA720196F)

UNIPROT #

P28907

PROTEIN NAME

Human CD38

SYNONYMS

Acute lymphoblastic leukemia cells antigen CD38 antibody;ADP ribosyl cyclase 1 antibody;ADP ribosyl cyclase antibody;ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody;ADP-ribosyl cyclase 1 antibody;ADPRC 1 antibody;ADPRC1 antibody;cADPr hydrolase 1 antibody;CD 38 antibody;CD38 antibody;CD38 antigen (p45) antibody;CD38 antigen antibody;CD38 molecule antibody;Cd38-rs1 antibody;CD38_HUMAN antibody;CD38H antibody;Cyclic ADP ribose hydrolase antibody;Cyclic ADP ribose hydrolase 1 antibody;Cyclic ADP-ribose hydrolase 1 antibody;EC 3.2.2.5 antibody;Ecto nicotinamide adenine dinucleotide glycohydrolase antibody;I-19 antibody;I19 (mouse) antibody;Lymphocyte differentiation antigen CD38 antibody;NAD(+) nucleosidase antibody;NIM-R5 antigen antibody;NIMR5 antigen (mouse) antibody;OTTHUMP00000158633 antibody;OTTHUMP00000217743 antibody;p45 antibody;T10 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.