FGL1 Recombinant Rabbit Monoclonal Antibody [PSH17-97] (HA723962)

UNIPROT #

Q08830

PROTEIN NAME

FGL1

SYNONYMS

FGL 1 antibody;Fgl1 antibody;FGL1_HUMAN antibody;Fibrinogen like 1 antibody;Fibrinogen like protein 1 antibody;Fibrinogen related protein 1 antibody;Fibrinogen-like protein 1 antibody;Hepassocin antibody;Hepatocellular carcinoma related sequence antibody;Hepatocyte derived fibrinogen related protein 1 antibody;Hepatocyte-derived fibrinogen-related protein 1 antibody;HFREP 1 antibody;HFREP-1 antibody;HFREP1 antibody;HP 041 antibody;HP-041 antibody;HP041 antibody;LFIRE 1 antibody;LFIRE-1 antibody;LFIRE1 antibody;Liver fibrinogen related protein 1 antibody;Liver fibrinogen-related protein 1 antibody;MFIRE 1 antibody;MGC108569 antibody;MGC12455 antibody;MGC37822 antibody;OTTHUMP00000122468 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene. It is classified as a hepatokine. Four splice variants exist for this gene. Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation. FGL-1 has also been observed to strongly bind to and activate LAG-3, a regulatory protein expressed on T cells. As LAG-3 has an important role in controlling activated T cells, manipulating FGL-1 binding to T cells has been proposed for both cancer immunotherapy and anti-inflammatory treatments.