Fetuin A Recombinant Rabbit Monoclonal Antibody [PSH20-01] (HA724121)

UNIPROT #

P02765

PROTEIN NAME

Fetuin A

SYNONYMS

59 kDa bone sialic acid containing protein antibody;A2HS antibody;Aa2 066 antibody;AHS antibody;Ahsg antibody;Alpha 2 HS glycoprotein antibody;Alpha 2 HS glycoprotein chain A antibody;Alpha 2 HS glycoprotein chain B antibody;Alpha 2 Z globulin antibody;Alpha 2HS glycoprotein antibody;Alpha-2-HS-glycoprotein chain B antibody;Alpha-2-Z-globulin antibody;alpha2 Heremans Schmid glycoprotein antibody;Asialofetuin antibody;Ba alpha 2 glycoprotein antibody;Ba-alpha-2-glycoprotein antibody;BSP antibody;Countertrypin antibody;FETUA antibody;FETUA_HUMAN antibody;Fetuin A antibody;Fetuin-A antibody;FetuinA antibody;HSGA antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

alpha-2-HS-glycoprotein (AHSG, Alpha-2-Heremans-Schmid Glycoprotein) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in fetal than adult blood. Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes and adipocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. The choroid plexus is an established extrahepatic expression site. The mature circulating AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. Multiple post-translational modifications have been reported. Thus AHSG is a secreted partially phosphorylated glycoprotein with complex proteolytic processing that circulates in blood and extracellular fluids. In the test tube AHSG can bind multiple ligands and therefore has been claimed to be involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Most of these functions await confirmation in vivo.