Fbx32 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JE41-27] (HA751828)

UNIPROT #

Q969P5

PROTEIN NAME

Fbx32

SYNONYMS

4833442G10Rik antibody;AI430017 antibody;Atrogin 1 antibody;Atrogin-1 antibody;ATROGIN1 antibody;Atrophy gene 1 antibody;F box only protein 32 antibody;F-box only protein 32 antibody;F-box protein 32 antibody;FBX32_HUMAN antibody;fbxo25 antibody;FBXO32 antibody;FLJ32424 antibody;MAFbx antibody;MGC108443 antibody;MGC137646 antibody;MGC33610 antibody;Muscle atrophy F box antibody;Muscle atrophy F box protein antibody;Muscle atrophy F-box protein antibody

TISSUE SPECIFICITY

Specifically expressed in cardiac and skeletal muscle.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase that initiates ATP-dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. MAFbx transcript is abundant in cardiac and skeletal muscle undergoing atrophy. MAFbx -/- mice are resistant to muscle atrophy. MAFbx is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. It interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. MAFbx is specifically expressed in cardiac and skeletal muscle.