Ezrin Recombinant Rabbit Monoclonal Antibody [PSH19-97] (HA724117)

UNIPROT #

P15311

PROTEIN NAME

Ezrin

SYNONYMS

Villin 2 ezrin antibody;CVIL antibody;CVL antibody;Cytovillin 2 antibody;Cytovillin antibody;DKFZp762H157 antibody;Epididymis secretory protein Li 105 antibody;EZR antibody;EZRI_HUMAN antibody;Ezrin antibody;FLJ26216 antibody;HEL S 105 antibody;MGC1584 antibody;p81 antibody;VIL 2 antibody;VIL2 antibody;Villin 2 (ezrin) antibody;Villin 2 antibody;Villin-2 antibody;Villin2 antibody

SUBCELLULAR LOCATION

Apical cell membrane, Cell projection, microvillus membrane, ruffle membrane, Cytoplasm, cell cortex, cytoskeleton, microvillus.

FUNCTION

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene. The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family. This protein serves as a linker between plasma membrane and actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. The N-terminal domain (also called FERM domain) binds sodium-hydrogen exchanger regulatory factor (NHERF) protein (involving long-range allostery). This binding can happen only when ezrin is in its active state. The activation of ezrin occurs in synergism of the two factors: 1) binding of the N-terminal domain to phosphatidylinositol(4,5)bis-phosphate (PIP2) and 2) phosphorylation of threonine T567 in the C-terminal domain. Binding to actin filaments (via C-terminal) and to membrane proteins (via N-terminal) stabilizes the protein's conformation in its active mode. The membrane proteins like CD44 and ICAM-2 are indirect binding partners of ezrin, while EBP50 (ERM binding protein 50) can associate with ezrin directly.