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ERK5 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SD2084] (HA750299)

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Catalog# HA750299

Rabbit Monoclonal to ERK5

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

ERK5 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SD2084] (HA750299)

Immunogen

Synthetic peptide within human erk5 aa 767-816 / 816.

Host

Rabbit

Positive Control

HeLa cell lysate, NIH/3T3 cell lysate, Neuro-2a cell lysate, mouse brain tissue lysate, mouse testis tissue lysate, PC-12 cell lysate, NIH/3T3, PC-12, HeLa.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD2084

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:100

  • IF-Tissue

  • 1:100-1:500

  • FC

  • 1:1,000

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 88 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13164

PROTEIN NAME

ERK5

SYNONYMS

Big MAP kinase 1 antibody;BMK 1 antibody;BMK 1 kinase antibody;BMK-1 antibody;BMK1 antibody;BMK1 Kinase antibody;EC 2.7.11.24 antibody;ERK 4 antibody;ERK 5 antibody;ERK-5 antibody;ERK4 antibody;ERK5 antibody;Extracellular signal regulated kinase 5 antibody;Extracellular signal-regulated kinase 5 antibody;MAP kinase 7 antibody;MAPK 7 antibody;MAPK7 antibody;Mitogen activated protein kinase 7 antibody;Mitogen-activated protein kinase 7 antibody;MK07_HUMAN antibody;OTTHUMP00000065906 antibody;OTTHUMP00000065907 antibody;PRKM 7 antibody;PRKM7 antibody;PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

TISSUE SPECIFICITY

Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.

POST-TRANSLATIONAL MODIFICATION

Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

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