ERCC1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM10-07] (HA750374)

UNIPROT #

P07992

PROTEIN NAME

ERCC1

SYNONYMS

COFS 4 antibody;COFS4 antibody;DNA excision repair protein ERCC 1 antibody;DNA excision repair protein ERCC-1 antibody;DNA excision repair protein ERCC1 antibody;ERCC 1 antibody;ERCC1 antibody;ERCC1_HUMAN antibody;Excision repair cross complementation group 1 antibody;Excision repair cross complementing 1 antibody;Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody;Excision repair protein antibody;RAD 10 antibody;RAD10 antibody;UV 20 antibody;UV20 antibody

SEQUENCE SIMILARITIES

Belongs to the ERCC1/RAD10/SWI10 family.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. Cells with disabling mutations in ERCC1 are more sensitive than normal to particular DNA damaging agents, including ultraviolet (UV) radiation and to chemicals that cause crosslinking between DNA strands. Genetically engineered mice with disabling mutations in ERCC1 have defects in DNA repair, accompanied by metabolic stress-induced changes in physiology that result in premature aging. Complete deletion of ERCC1 is incompatible with viability of mice, and no human individuals have been found with complete (homozygous) deletion of ERCC1. Rare individuals in the human population harbor inherited mutations that impair the function of ERCC1. When the normal genes are absent, these mutations can lead to human syndromes, including Cockayne syndrome (CS) and COFS.