EAAT2 Recombinant Antibody [PS01-62] - Guinea pig IgG2 (Chimeric) (HA601504)

UNIPROT #

P43006

PROTEIN NAME

EAAT2

SYNONYMS

EAA2_HUMAN antibody;EAAT2 antibody;Excitatory amino acid transporter 2 antibody;Excitotoxic amino acid transporter 2 antibody;Glial high affinity glutamate transporter antibody;GLT 1 antibody;GLT1 antibody;Glutamate aspartate transporter II antibody;Glutamate transporter 1 antibody;Glutamate/aspartate transporter II antibody;Slc1a2 antibody;Sodium dependent glutamate aspartate transporter 2 antibody;Sodium-dependent glutamate/aspartate transporter 2 antibody;solute carrier family 1 (glial high affinity glutamate transporter), member 2 antibody;Solute carrier family 1 glial high affinity glutamate transporter member 2 antibody;Solute carrier family 1 member 2 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 (GLT-1) is a protein that in humans is encoded by the SLC1A2 gene. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. SLC1A2 / EAAT2 is a member of a family of the solute carrier family of proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. EAAT2 is responsible for over 90% of glutamate reuptake within the brain.