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dsRNA Recombinant Mouse Monoclonal Antibody - BSA and Azide free [PSH25-25] (HA610432)

Price: Regular price $649.00

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Catalog# HA610432

Mouse Monoclonal to dsRNA

Tested for

  • IF-Cell

Reacts with

  • Species independent

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Mouse monoclonal primary

Product Name

dsRNA Recombinant Mouse Monoclonal Antibody - BSA and Azide free [PSH25-25] (HA610432)

Host

Mouse

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH25-25

APPLICATION DILUTION

  • IF-Cell

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Isotype

IgG1

TARGET

PROTEIN NAME

dsRNA

FUNCTION

Double-stranded RNA (dsRNA) is produced during the replication cycle of a broad range of viruses and can trigger the innate immune response. dsRNA is present if cells are infected with a dsRNA virus or it can be generated during the course of single-stranded RNA (ssRNA) virus replication. Host cells do not produce dsRNA so the innate immune response can differentiate between host and viral RNAs by the presence of dsRNA. The innate immune response is controlled by several classes of germline-encoded pattern-recognition receptors (PRRs), including retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), Toll-like receptors (TLRs), and NOD-like receptors (NLRs) that sense viral components, such as dsRNA, ssRNA, and DNA. Activation of PRRs by dsRNA leads to production of type I interferons (IFNs) and proinflammatory cytokines, triggering the adaptive immune response. Understanding how antiviral responses are initiated, the counter strategies that viruses adopt, and exploring the viral life cycle gives researchers a better comprehension of how to treat infections of different viral diseases.

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