Dopamine D2 Receptor Recombinant Rabbit Monoclonal Antibody [PSH09-94] (HA723163)

UNIPROT #

P14416

PROTEIN NAME

Dopamine D2 Receptor

SYNONYMS

D(2) dopamine receptor antibody;D2 dopamine receptor antibody;D2DR antibody;D2R antibody;Dopamine D2 receptor antibody;Dopamine receptor D2 antibody;DRD 2 antibody;DRD2 antibody;DRD2_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus membrane.

FUNCTION

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined. D2 receptors are coupled to Gi subtype of G protein. This G protein-coupled receptor inhibits adenylyl cyclase activity. In mice, regulation of D2R surface expression by the neuronal calcium sensor-1 (NCS-1) in the dentate gyrus is involved in exploration, synaptic plasticity and memory formation. Studies have shown potential roles for D2R in retrieval of fear memories in the prelimbic cortex and in discrimination learning in the nucleus accumbens. In flies, activation of the D2 autoreceptor protected dopamine neurons from cell death induced by MPP+, a toxin mimicking Parkinson's disease pathology. While optimal dopamine levels favor D1R cognitive stabilization, it is the D2R that mediates the cognitive flexibility in humans.