DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM93-12] (HA750423)

UNIPROT #

P06746

PROTEIN NAME

DNA Polymerase beta

SYNONYMS

DNA directed DNA polymerase beta antibody;DNA pol beta antibody;DNA polymerase beta antibody;DNA polymerase beta subunit antibody;DPOLB_HUMAN antibody;MGC125976 antibody;Pol B antibody;Pol beta antibody;POLB antibody;Polymerase (DNA directed) beta antibody

SEQUENCE SIMILARITIES

Belongs to the DNA polymerase type-X family.

POST-TRANSLATIONAL MODIFICATION

Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.; Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

DNA polymerase beta, also known as POLB, is an enzyme present in eukaryotes. In humans, it is encoded by the POLB gene. In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. The mitochondrial DNA of mammalian cells is constantly under attack from oxygen radicals released during ATP production. Mammalian cell mitochondria contain an efficient base excision repair system employing POLB that removes some frequent oxidative DNA damages. POLB thus has a key role in maintaining the stability of the mitochondrial genome. An analysis of the fidelity of DNA replication by polymerase beta in the neurons from young and very aged mice indicated that aging has no significant effect on the fidelity of DNA synthesis by polymerase beta. This finding was considered to provide evidence against the error catastrophe theory of aging.