DHODH Recombinant Rabbit Monoclonal Antibody [PSH09-69] (HA723134)

UNIPROT #

Q02127

PROTEIN NAME

DHODH

SYNONYMS

DHOdehase antibody;Dhodh antibody;Dihydroorotate dehydrogenase (quinone) antibody;Dihydroorotate dehydrogenase antibody;Dihydroorotate dehydrogenase mitochondrial antibody;Dihydroorotate oxidase antibody;Human complement of yeast URA1 antibody;mitochondrial antibody;POADS antibody;PYRD_HUMAN antibody;URA1 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM). Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis. Human DHODH is a ubiquitous FMN flavoprotein. In bacteria (gene pyrD), it is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1), it is a cytosolic protein, whereas, in other eukaryotes, it is found in the mitochondria. It is also the only enzyme in the pyrimidine biosynthesis pathway located in the mitochondria rather than the cytosol.