DDX58 Recombinant Rabbit Monoclonal Antibody [JE60-05] (HA720090)

UNIPROT #

O95786

PROTEIN NAME

DDX58

SYNONYMS

Ddx58 antibody;DDX58_HUMAN antibody;DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody;DEAD (Asp Glu Ala Asp/His) box polypeptide antibody;DEAD box protein 58 antibody;DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody;DKFZp434J1111 antibody;DKFZp686N19181 antibody;FLJ13599 antibody;Probable ATP dependent RNA helicase DDX58 antibody;Probable ATP-dependent RNA helicase DDX58 antibody;Retinoic acid inducible gene 1 protein antibody;Retinoic acid-inducible gene 1 protein antibody;Retinoic acid-inducible gene I protein antibody;RIG I antibody;Rig-1 antibody;RIG-I antibody;RIG1 antibody;rigi antibody;RLR 1 antibody;RNA helicase antibody;RNA helicase RIG I antibody;SGMRT2 antibody

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction.

FUNCTION

Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons.