Cytokeratin 18 Recombinant Rabbit Monoclonal Antibody (IRS224RB)

UNIPROT #

P05784

PROTEIN NAME

Cytokeratin 18

SYNONYMS

Cell proliferation inducing gene 46 protein antibody;Cell proliferation inducing protein 46 antibody;Cell proliferation-inducing gene 46 protein antibody;CK 18 antibody;CK-18 antibody;CK18 antibody;CYK 18 antibody;CYK18 antibody;Cytokeratin 18 antibody;Cytokeratin endo B antibody;Cytokeratin-18 antibody;K 18 antibody;K18 antibody;K1C18_HUMAN antibody;KA18 antibody;Keratin 18 antibody;Keratin 18, type I antibody;Keratin D antibody;keratin, type I cytoskeletal 18 antibody;Keratin-18 antibody;Krt18 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, Cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while Cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Cytokeratin 18 contains two major phosphorylation sites on Ser 33 and Ser 52. Phosphorylation of Ser 18 is essential for the association of Cytokeratin 18 with 14-3-3 proteins and is involved in keratin organization and distribution.