Cytokeratin 14 Recombinant Rabbit Monoclonal Antibody (IRS162RB)

UNIPROT #

P02533

PROTEIN NAME

Cytokeratin 14

SYNONYMS

CK 14 antibody;CK-14 antibody;ck14 antibody;Cytokeratin 14 antibody;Cytokeratin-14 antibody;Cytokeratin14 antibody;Dowling Meara antibody;EBS3 antibody;EBS4 antibody;Epidermolysis bullosa simplex antibody;K14 antibody;K1C14_HUMAN antibody;Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) antibody;Keratin 14 antibody;Keratin antibody;Keratin type I cytoskeletal 14 antibody;Keratin, type I cytoskeletal 14 antibody;Keratin-14 antibody;Keratin14 antibody;Koebner antibody;Krt 14 antibody;Krt14 antibody;NFJ antibody;OTTHUMP00000164624 antibody;type I cytoskeletal 14 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Expressed in the corneal epithelium (at protein level). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS1A is an autosomal dominant form characterized by generalized intraepidermal skin blistering that begins and is very prominent at birth. EBS1A may be life-threatening in the first year of life. Tendency to blistering diminishes in adolescence.