CYLD Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH11-22] (HA751631)

UNIPROT #

Q9NQC7

PROTEIN NAME

CYLD

SYNONYMS

BRSS antibody;CDMT antibody;Cyld antibody;CYLD gene antibody;CYLD_HUMAN antibody;CYLD1 antibody;CYLDI antibody;cylindromatosis (turban tumor syndrome) antibody;cylindromatosis 1 antibody;Deubiquitinating enzyme CYLD antibody;EAC antibody;HSPC057 antibody;KIAA0849 antibody;MFT antibody;MFT1 antibody;Probable ubiquitin carboxyl terminal hydrolase CYLD antibody;SBS antibody;TEM antibody;turban tumor syndrome antibody;Ubiquitin carboxyl-terminal hydrolase CYLD antibody;ubiquitin specific peptidase like 2 antibody;ubiquitin thioesterase CYLD antibody;Ubiquitin thiolesterase CYLD antibody;Ubiquitin-specific processing protease CYLD antibody;Ubiquitin-specific-processing protease CYLD antibody;USPL2 antibody

SUBCELLULAR LOCATION

Cytoplasm, perinuclear region, cytoskeleton, Cell membrane, microtubule organizing center, centrosome, spindle, cilium basal body.

FUNCTION

The CYLD lysine 63 deubiquitinase gene, also termed the CYLD gene, CYLD is an evolutionary ancient gene found to be present as far back on the evolutionary scale as in sponges. In humans, this gene is located in band 12.1 on the long (or "q") arm of chromosome 16 and is known to code (i.e. direct the production of) multiple proteins through the process of alternative splicing. The CYLD gene in known to code for a cytoplasmic protein, termed CYLD lysine 63 deubiquitinase (here termed CYLD protein), which has three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains (areas or the protein controlling critical functions). CYLD protein is a deubiquitinating enzyme, i.e. a protease that removes ubiquitin from certain proteins and thereby regulates these proteins' activities. CYLD protein removes ubiquitin from proteins involved in regulating the NF-κB, Wnt, notch, TGF-β, and JNK cell signaling pathways; these pathways normally act to regulate hair formation, cell growth, cell survival, inflammatory responses, and/or tumor development.