CXCR4 Recombinant Rabbit Monoclonal Antibody [PSH22-76] (HA724321)

UNIPROT #

P61073

PROTEIN NAME

CXCR4

SYNONYMS

C-X-C chemokine receptor type 4 antibody;CD184 antibody;CD184 antigen antibody;Chemokine (C X C motif) receptor 4 antibody;Chemokine CXC Motif Receptor 4 antibody;CXC-R4 antibody;CXCR-4 antibody;CXCR4 antibody;CXCR4_HUMAN antibody;D2S201E antibody;FB22 antibody;Fusin antibody;HM89 antibody;HSY3RR antibody;LAP 3 antibody;LAP3 antibody;LCR1 antibody;LESTR antibody;Leukocyte derived seven transmembrane domain receptor antibody;Leukocyte-derived seven transmembrane domain receptor antibody;Lipopolysaccharide associated protein 3 antibody;Neuropeptide Y receptor Y3 antibody;NPY3R antibody;NPYR antibody;NPYRL antibody;NPYY3 antibody;NPYY3R antibody;Probable G protein coupled receptor lcr1 homolog antibody;SDF 1 receptor antibody;SDF-1 receptor antibody;SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody;Stromal cell derived factor 1 receptor antibody;Stromal cell-derived factor 1 receptor antibody;WHIM antibody;WHIMS antibody

SUBCELLULAR LOCATION

Cell membrane, Cell junction, Early endosome, Late endosome, Lysosome.

FUNCTION

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene. The protein is a CXC chemokine receptor. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency.