CX3CR1 Recombinant Rabbit Monoclonal Antibody (IRS250RB)

UNIPROT #

Q9Z0D9

PROTEIN NAME

CX3CR1

SYNONYMS

Beta chemokine receptor-like 1 antibody;C X3 C CKR 1 antibody;C-X3-C CKR-1 antibody;CCRL1 antibody;Chemokine C X3 C motif receptor 1 antibody;CMK BRL 1 antibody;CMK-BRL-1 antibody;CMK-BRL1 antibody;CMKBLR1 antibody;CMKDR1 antibody;CX3C chemokine receptor 1 antibody;CX3C CKR1 antibody;CX3CR1 antibody;Fractalkine receptor antibody;G-protein coupled receptor 13 antibody;GPR13 antibody;GPRV28 antibody;V28 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family and the only known member of the CX3C chemokine receptor subfamily. As the name suggests, this receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in humans). This endogenous ligand solely binds to CX3CR1 receptor. Interaction of CX3CR1 with CX3CL1 can mediate migration, adhesion and retention of leukocytes, because Fractalkine exists as membrane-anchored protein (mCX3CL1) as well as cleaved soluble molecule (sCX3CL1) due to proteolysis by metalloproteinases (MPPs). The shedded form carries out typical function of conventional chemokines, the chemotaxis, while the membrane-bound protein behaves as adhesion molecule for facilitation of diapedesis.