CTLA-4 Recombinant Rabbit Monoclonal Antibody (IRS016)

UNIPROT #

P16410

PROTEIN NAME

CTLA-4

SYNONYMS

ALPS5 antibody;CD 152 antibody;CD antibody;CD152 antibody;CD152 antigen antibody;CD152 isoform antibody;Celiac disease 3 antibody;CELIAC3 antibody;CTLA 4 antibody;CTLA-4 antibody;CTLA4 antibody;CTLA4_HUMAN antibody;Cytotoxic T cell associated 4 antibody;Cytotoxic T lymphocyte antigen 4 antibody;Cytotoxic T lymphocyte associated 4 antibody;Cytotoxic T lymphocyte associated 4, soluble isoform, included antibody;Cytotoxic T lymphocyte associated antigen 4 antibody;Cytotoxic T lymphocyte associated antigen 4 short spliced form antibody;Cytotoxic T lymphocyte associated protein 4 antibody;Cytotoxic T lymphocyte associated serine esterase 4 antibody;Cytotoxic T lymphocyte protein 4 antibody;Cytotoxic T-lymphocyte protein 4 antibody;Cytotoxic T-lymphocyte-associated antigen 4 antibody;GRD4 antibody;GSE antibody;ICOS antibody;IDDM12 antibody;insulin-dependent diabetes mellitus 12 antibody;Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody;OTTHUMP00000216623 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as rheumatoid arthritis, autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In systemic lupus erythematosus (SLE), the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active SLE. Germline haploinsufficiency of CTLA-4 leads to CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration), a rare genetic disorder of the immune system. Symptomatic patients with CTLA-4 mutations are characterized by an immune dysregulation syndrome including extensive T cell infiltration in a number of organs, including the gut, lungs, bone marrow, central nervous system. Once a diagnosis is made, the treatment is based on an individual’s clinical condition and may include standard management for autoimmunity and immunoglobulin deficiencies. The comparatively higher binding affinity of CTLA-4 than CD28 has made it a potential therapy for autoimmune diseases.