Collagen VI Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SD83-03] (HA750305)

UNIPROT #

P12109

PROTEIN NAME

Collagen VI

SYNONYMS

Alpha 1 (VI) chain (61 AA) antibody;CO6A1_HUMAN antibody;COL6A1 antibody;Collagen alpha-1(VI) chain antibody;Collagen type VI alpha 1 antibody;Collagen VI alpha 1 polypeptide antibody;CollagenVI antibody;Human mRNA for collagen VI alpha 2 C terminal globular domain antibody;OPLL antibody;PP3610 antibody

SEQUENCE SIMILARITIES

Belongs to the type VI collagen family.

POST-TRANSLATIONAL MODIFICATION

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

SUBCELLULAR LOCATION

Extracellular matrix.

FUNCTION

Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle function and stabilizes the cell membrane. It is synthesized by a complex, multistep pathway that leads to the formation of a unique network of linked microfilaments located in the extracellular matrix (ECM). ColVI plays a vital role in numerous cell types, including chondrocytes, neurons, myocytes, fibroblasts, and cardiomyocytes. ColVI molecules are made up of three alpha chains: α1(VI), α2(VI), and α3(VI). It is encoded by 6 genes: COL6A1, COL6A2, COL6A3, COL6A4, COL6A5, and COL6A6. The chain lengths of α1(VI) and α2(VI) are about 1,000 amino acids. The chain length of α3(VI) is roughly a third larger than those of α1(VI) and α2(VI), and it consists of several spliced variants within the range of 2,500 to 3,100 amino acids. The first two alpha chains subunits of ColVI have a molecular weight of 140-150 KDa and the third polypeptide chain is larger with a molecular weight of 250-300kDa. ColVI is also found in the skin, lungs, blood vessels, cornea and intervertebral disc. It also forms part of the peripheral nerves, brain, myocardium and adipose tissue.