Claudin 11 Recombinant Rabbit Monoclonal Antibody [PSH25-21] (HA724515)

UNIPROT #

Q60771

PROTEIN NAME

Claudin 11

SYNONYMS

Claudin-11;Oligodendrocyte transmembrane protein;Oligodendrocyte-specific protein;Cldn11;Osp;Otm

SUBCELLULAR LOCATION

Cell junction, tight junction, Cell membrane.

FUNCTION

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function, hearing, and spermatogenesis. There is growing evidence that the protein determines the permeability between layers of myelin sheaths and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. Finally, experiments in Cldn11-null mice demonstrate that behavioral phenotypes in open field tests, as well as defects in sound lateralization, accompany changes in neurotransmitter levels in the amygdala/ventral hippocampus and auditory brainstem. This study reveals a molecular mechanism by which changes to myelin membrane properties in the absence of degenerative pathology, could lead to neuropsychiatric disease in humans.