Chromogranin A Mouse Monoclonal Antibody (IRS132MS)

UNIPROT #

P10645

PROTEIN NAME

Chromogranin A

SYNONYMS

beta Granin antibody;betagranin (N-terminal fragment of chromogranin A) antibody;catestatin antibody;CgA antibody;CHG A antibody;Chga antibody;chromofungin antibody;Chromogranin A antibody;Chromogranin A parathyroid secretory protein 1 antibody;Chromogranin A precursor antibody;ChromograninA antibody;CMGA_HUMAN antibody;ER-37 antibody;Pancreastatin antibody;Parastatin antibody;Parathyroid secretory protein 1 antibody;Pituitary secretory protein I antibody;Secretory protein I antibody;SP I antibody;SP-I antibody;SP1 antibody;SPI antibody;vasostatin 2 antibody;Vasostatin antibody;Vasostatin I antibody;Vasostatin II antibody;vasostatin-2 antibody

SUBCELLULAR LOCATION

Cytoplasmic vesicle, Secreted.

FUNCTION

Strongly inhibits glucose induced insulin release from the pancreas.Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro tion and blood pressure .Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.