CD98 Mouse Monoclonal Antibody (IRS130MS)

UNIPROT #

P08195

PROTEIN NAME

CD98

SYNONYMS

4F2 antibody;4F2 cell surface antigen heavy chain antibody;4F2 cell-surface antigen heavy chain antibody;4F2 heavy chain antibody;4F2 heavy chain antigen antibody;4F2_HUMAN antibody;4F2hc antibody;4T2HC antibody;Antigen defined by monoclonal antibody 4F2 heavy chain antibody;Antigen identified by monoclonal antibodies 4F2 TRA1.10 TROP4 and T43 antibody;CD 98 antibody;CD98 antibody;CD98 antigen antibody;CD98 heavy chain antibody;CD98HC antibody;Heavy chain antibody;Lymphocyte activation antigen 4F2 large subunit antibody;MDU 1 antibody;MDU1 antibody;Monoclonal antibody 44D7 antibody;NACAE antibody;Slc3a2 antibody;Solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2 antibody;Solute carrier family 3 member 2 antibody

SUBCELLULAR LOCATION

Apical cell membrane, Cell membrane, Cell junction, Lysosome membrane.

FUNCTION

Component of several heterodimeric complexes involved in amino acid transport. The precise substrate specificity depends on the other subunit in the heterodimer. The complexes function as amino acid exchangers. The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids. The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane. The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine. When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier. The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals. Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier.