CD8 Rabbit Polyclonal Antibody (IRS083)

UNIPROT #

P01731

PROTEIN NAME

CD8

SYNONYMS

alpha polypeptide (p32) antibody;CD_antigen=CD8a antibody;CD8 antibody;CD8 antigen alpha polypeptide antibody;CD8 antigen alpha polypeptide (p32) antibody;CD8 antigen, alpha polypeptide (p32) antibody;CD8a antibody;CD8A antigen antibody;CD8A molecule antibody;CD8A_HUMAN antibody;Leu2 antibody;Leu2 T lymphocyte antigen antibody;Ly 2 antibody;Ly 35 antibody;Ly B antibody;Ly2 antibody;Ly3 antibody;Ly35 antibody;LyB antibody;Lyt 2.1 lymphocyte differentiation antigen (AA at 100) antibody;LYT3 antibody;MAL antibody;OKT8 T cell antigen antibody;OTTHUMP00000160760 antibody;OTTHUMP00000160764 antibody;OTTHUMP00000203528 antibody;OTTHUMP00000203721 antibody;p32 antibody;T cell antigen Leu2 antibody;T cell co receptor antibody;T lymphocyte differentiation antigen T8/Leu 2 antibody;T-cell surface glycoprotein CD8 alpha chain antibody;T-cell surface glycoprotein Lyt 2 antibody;T-lymphocyte differentiation antigen T8/Leu-2 antibody;T8 T cell antigen antibody;T8/Leu-2 T-lymphocyte differentiation antigen antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.