CD66b Rabbit Polyclonal Antibody (IRS127RB)

UNIPROT #

P31997

PROTEIN NAME

CD66b

SYNONYMS

Carcinoembryonic antigen CGM6 antibody;Carcinoembryonic antigen gene family member 6 antibody;Carcinoembryonic antigen related cell adhesion molecule 8 antibody;Carcinoembryonic antigen-related cell adhesion molecule 8 antibody;CD 66b antibody;CD 67 antibody;CD66b antibody;CD66b antigen antibody;CD67 antibody;CD67 antigen antibody;CEACAM 8 antibody;CEACAM8 antibody;CEAM8_HUMAN antibody;CGM 6 antibody;CGM6 antibody;NCA 95 antibody;NCA95 antibody;Non-specific cross-reacting antigen NCA-95 antibody;Nonspecific cross reacting antigen NCA 95 antibody;Nonspecific cross reacting antigen NCA95 antibody

SUBCELLULAR LOCATION

Cell membrane, Cell surface.

FUNCTION

Carcinoembryonic antigen-related cell adhesion molecule 8, also designated CD67, CD66b or nonspecific cross-reacting antigen (NCA-95), belongs to the human carcinoembryonic antigen (CEA) family. The CD67 antigen is encoded by the CEACAM8 (CGM6) gene, which is exclusively expressed in neutrophils and eosinophils. In neutrophils, the CEACAM8 gene is primarily detected in the secondary granules within the cytoplasm, but it can also be found in lower amounts on the plasma membrane. The amount of CD67 on the plasma membrane is up-regulated upon granulocyte activation. CD67 has been located on the surface of neutrophilic and eosinophilic granulocytes at late stages of differentiation. It exhibits heterophilic cell adhesion properties with CD66c, which is coexpressed with CD67 in granulocytes. CD67, which is attached to the membrane by a GPI-anchor, is expressed in leukocytes of chronic myeloid leukemia patients and bone marrow and in granulocytes in the spleen, thymus and lungs.