CD63 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SY21-02] (HA750112)

UNIPROT #

P08962

PROTEIN NAME

CD63

SYNONYMS

Lysosomal associated membrane protein 3 antibody;CD 63 antibody;CD63 antibody;CD63 antigen (melanoma 1 antigen) antibody;CD63 antigen antibody;CD63 antigen melanoma 1 antigen antibody;CD63 molecule antibody;CD63_HUMAN antibody;gp55 antibody;Granulophysin antibody;LAMP 3 antibody;LAMP-3 antibody;LAMP3 antibody;LIMP antibody;Lysosomal-associated membrane protein 3 antibody;Lysosome associated membrane glycoprotein 3 antibody;Mast cell antigen AD1 antibody;ME491 antibody;Melanoma 1 antigen antibody;Melanoma associated antigen ME491 antibody;Melanoma associated antigen MLA1 antibody;Melanoma-associated antigen ME491 antibody;MGC72893 antibody;MLA 1 antibody;MLA1 antibody;NGA antibody;Ocular melanoma associated antigen antibody;Ocular melanoma-associated antigen antibody;OMA81H antibody;PTLGP40 antibody;Tetraspanin 30 antibody;Tetraspanin-30 antibody;Tspan 30 antibody;Tspan-30 antibody;TSPAN30 antibody

SEQUENCE SIMILARITIES

Belongs to the tetraspanin (TM4SF) family.

TISSUE SPECIFICITY

Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).

SUBCELLULAR LOCATION

Lysosome membrane, Cell membrane, extracellular exosome, Late endosome membrane, multivesicular body, Melanosome, Cell surface.

FUNCTION

The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 (also known as LAMP-3, Melanoma-associated antigen ME491, TSPAN30, MLA1 and OMA81H) is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome.