CD47 Recombinant Rabbit Monoclonal Antibody [PSH10-31] (HA723198)

UNIPROT #

Q08722

PROTEIN NAME

CD47

SYNONYMS

Antigen identified by monoclonal antibody 1D8 antibody;Antigenic surface determinant protein OA3 antibody;CD 47 antibody;CD47 antibody;CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody;CD47 antigen antibody;CD47 glycoprotein antibody;CD47 molecule antibody;CD47_HUMAN antibody;IAP antibody;Integrin Associated Protein antibody;Integrin associated signal transducer antibody;Integrin-associated protein antibody;Leukocyte surface antigen CD47 antibody;MER 6 antibody;MER6 antibody;OA 3 antibody;OA3 antibody;OTTHUMP00000041152 antibody;OTTHUMP00000041153 antibody;Protein MER6 antibody;Rh related antigen antibody;Surface antigen identified by monoclonal antibody 1D8 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a role in insulin secretion, as well as immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.