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CD44 Recombinant Rabbit Monoclonal Antibody (IRS122RB)

Price: Regular price $278.00

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Catalog# IRS122RB

Monoclonal to CD44

Tested for

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CD44 Recombinant Rabbit Monoclonal Antibody (IRS122RB)

Immunogen

Synthetic peptide within human cd44 aa 150-190.

Positive Control

Human tonsil tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 82 kDa

Isotype

IgG

TARGET

UNIPROT #

P16070

PROTEIN NAME

CD44

SYNONYMS

LHR antibody;BA-1 antibody;CD 44 antibody;CD44 antibody;CD44 antigen antibody;CD44 molecule (Indian blood group) antibody;CD44 molecule antibody;CD44_HUMAN antibody;CDw44 antibody;Cell surface glycoprotein CD44 antibody;chondroitin sulfate proteoglycan 8 antibody;CSPG8 antibody;ECMR-III antibody;Epican antibody;Extracellular matrix receptor III antibody;GP90 lymphocyte homing/adhesion receptor antibody;HCELL antibody;hematopoietic cell E- and L-selectin ligand antibody;Heparan sulfate proteoglycan antibody;Hermes antigen antibody;homing function and Indian blood group system antibody;HSA antibody;HUTCH-I antibody;HUTCH1 antibody;Hyaluronate receptor antibody;IN antibody;MC56 antibody;MDU2 antibody;MDU3 antibody;MGC10468 antibody;MIC4 antibody;MUTCH1 antibody;PGP-1 antibody;PGP-I antibody;PGP1 antibody;Phagocytic glycoprotein 1 antibody;Phagocytic glycoprotein I antibody;Soluble CD44 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cell adhesion molecules (CAMs) are a family of closely related, cell surface glycoproteins that are involved in cell-cell interactions and are thought to play an important role in embryogenesis and development. HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I or ECMR-III, is a 742 amino acid single-pass type I membrane protein that is involved in hematopoiesis, lymphocyte activation and tumor metastasis. Functioning as a receptor for hyaluronic acid (HA) and interacting with ligands such as osteopontin (OPN), HCAM mediates both cell-cell and cell-matrix interactions, thereby playing an essential role in cell adhesion and cell migration. HCAM contains one Link domain and, due to alternative splicing events, is expressed as multiple isoforms, some of which are designated CD44R, CDw44, CD44S, CD44H (hematopoietic) and CD44E (epithelial). While most of the HCAM splice varients are expressed in tissues throughout the body, one specific isoform, namely CD44H, is expressed at high levels in cancer tissue, suggesting an important role for the CD44H splice varient in tumor progression.

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