CD40 Recombinant Rabbit Monoclonal Antibody [PSH10-01] (HA723170)

UNIPROT #

P25942

PROTEIN NAME

CD40

SYNONYMS

AI326936 antibody;B cell associated molecule CD40 antibody;B cell surface antigen CD40 antibody;B cell-associated molecule antibody;B-cell surface antigen CD40 antibody;Bp50 antibody;CD 40 antibody;CD40 antibody;CD40 antigen (TNF receptor superfamily member 5) antibody;CD40 antigen antibody;CD40 molecule antibody;CD40 molecule, TNF receptor superfamily member 5 antibody;CD40 protein antibody;CD40 type II isoform antibody;CD40L receptor antibody;CDw40 antibody;GP39 antibody;HIGM1 antibody;IGM antibody;IMD3 antibody;MGC9013 antibody;Nerve growth factor receptor related B lymphocyte activation molecule antibody;OTTHUMP00000031699 antibody;OTTHUMP00000031700 antibody;p50 antibody;T-BAM antibody;TBAM antibody;TNF receptor superfamily member 5 antibody;TNFRSF5 antibody;TNR5_HUMAN antibody;TRAP antibody;Tumor necrosis factor receptor superfamily , member 5 antibody;Tumor necrosis factor receptor superfamily member 5 antibody;Tumor necrosis factor receptor superfamily member 5 precursor antibody;Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody

SUBCELLULAR LOCATION

Cell membrane. Secreted.

FUNCTION

Resting B cells can be activated and clonally expanded into antibody-producing cells in response to a combination of cell contact and soluble signals provided by primed helper T (Th) cells. A receptor ligand pair central to the trans-mission of this signal is CD40, expressed on the surface of B cells, together with CD40L, expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. B cells are sensitive to these cytokines only subsequent to CD40/CD40L-driven DNA synthesis. A downstream mediator of the CD40 signaling pathway, designated CRAF, is a member of an expanding family of proteins that contain a conserved cysteine- and histidine-rich RING finger motif.