CD19 Recombinant Monoclonal Antibody (IRS110RB)

UNIPROT #

P25918

PROTEIN NAME

CD19

SYNONYMS

Antibody deficiency due to defect in CD19 antibody;Antibody deficiency due to defect in CD19, included antibody;AW495831 antibody;B lymphocyte antigen CD19 antibody;B lymphocyte surface antigen B4 antibody;B-lymphocyte antigen CD19 antibody;B-lymphocyte surface antigen B4 antibody;B4 antibody;CD19 antibody;CD19 antigen antibody;CD19 molecule antibody;Cd19 protein antibody;CD19_HUMAN antibody;CVID3 antibody;Differentiation antigen CD19 antibody;Leu 12 antibody;Leu-12 antibody;Leu12 antibody;MGC109570 antibody;MGC12802 antibody;T-cell surface antigen Leu-12 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane raft.

FUNCTION

B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19, as confirmed by others. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.