CD163 Rabbit Polyclonal Antibody (IRS109RB)

UNIPROT #

Q2VLH6

PROTEIN NAME

CD163

SYNONYMS

CD 163 antibody;CD163 antibody;CD163 antigen antibody;CD163 molecule antibody;Hemoglobin scavenger receptor antibody;M130 antibody;M130 antigen precursor antibody;Macrophage associated antigen antibody;MM130 antibody;OTTHUMP00000238617 antibody;OTTHUMP00000238618 antibody;OTTHUMP00000238619 antibody;OTTHUMP00000238620 antibody;SCARI1 antibody;Scavenger receptor cysteine rich type 1 protein M130 antibody;sCD163 antibody;Soluble CD163 antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

CD163, also designated M130, is a macrophage-associated antigen that is a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is highly expressed on macrogphages and to a lesser extent on monocytes. The acute phase-regulated and signal-inducing macrophage protein, CD163, is a receptor that scavenges hemoglobin by mediating endocytosis of haptoglobin-hemoglobin complexes. CD163 binds only haptoglobin and hemoglobin in complex, which indicates the exposure of a receptor-binding neoepitope. The receptor-ligand interaction is calcium-dependent and of high affinity. The existence of several CD163 isoforms, which differ in the structure of their cytoplasmic domains and putative phosphorylation sites, suggests that these isoforms also differ in their signaling mechanism. The gene which encodes CD163 maps to human chromosome 12p13.31.