CD16 Recombinant Antibody [PD00-12] - Mouse IgG1 (Chimeric) (HA601634)

UNIPROT #

P08637

PROTEIN NAME

CD16

SYNONYMS

CD 16 antibody;CD 16a antibody;CD16 antibody;CD16a antibody;CD16a antigen antibody;CD16B antibody;CD16b antigen antibody;Fc fragment of IgG antibody;Fc fragment of IgG low affinity IIIa receptor (CD16) antibody;Fc fragment of IgG low affinity IIIa receptor antibody;Fc fragment of IgG receptor IIIa antibody;Fc fragment of IgG, low affinity III, receptor (CD16) antibody;Fc fragment of IgG, low affinity III, receptor for (CD16) antibody;Fc fragment of IgG, low affinity IIIa, receptor (CD16) antibody;Fc fragment of IgG, low affinity IIIa, receptor (CD16a) antibody;Fc fragment of IgG, low affinity IIIa, receptor for antibody;Fc fragment of IgG, low affinity IIIb, receptor (CD16b) antibody;Fc fragment of IgG, low affinity IIIb, receptor for (CD16) antibody;Fc gamma R3 antibody;Fc gamma receptor III 2 (CD 16) antibody;Fc gamma receptor III A antibody;Fc gamma receptor IIIA antibody;Fc gamma receptor IIIb (CD 16) antibody;Fc gamma RIII alpha antibody;Fc gamma RIII antibody;Fc gamma RIII beta antibody;Fc gamma RIIIa antibody;Fc gamma RIIIb antibody;Fc of IgG antibody;Fc-gamma receptor III2 (CD 16) antibody;Fc-gamma receptor III2 (CD16) antibody;Fc-gamma receptor IIIb (CD16) antibody;Fc-gamma RIII antibody;Fc-gamma RIII-alpha antibody;Fc-gamma RIIIa antibody;FCG 3 antibody;FCG3 antibody;FCG3A_HUMAN antibody;FCgammaRIIIA antibody;FCGR 3 antibody;FCGR 3A antibody;FCGR3 antibody;FCGR3A antibody;FCGR3A protein antibody;FCGRIII antibody;FCGRIII-2 antibody;FcR 10 antibody;FcR-10 antibody;FcR10 antibody;FcRIII antibody;FcRIIIa antibody;IGFR 3 antibody;IGFR3 antibody;IgG Fc receptor III 1 antibody;IgG Fc receptor III 2 antibody;IgG Fc receptor III-2 antibody;IMD20 antibody;immunoglobulin G Fc receptor III antibody;immunoglobulin G Fc receptor III-2 antibody;Low affinity IIIa receptor antibody;Low affinity immunoglobulin gamma Fc region receptor III A antibody;Low affinity immunoglobulin gamma Fc region receptor III-A antibody;Low affinity immunoglobulin gamma Fc region receptor IIIB antibody;neutrophil-specific antigen NA antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. CD16 (FcγRIII) is a low affinity Fc receptor that binds to IgG antibodies. Two forms of the receptor, CD16A (FcγRIIIa) and CD16B (FcγRIIIb) are present in natural killer cells, neutrophils, monocytes and activated macrophages. Antibody-dependent cell-mediated cytotoxicity (ADCC), cytokine release and microbe killing can be induced upon binding with CD16. Sconocchia, et al. demonstrated in a recent study that colorectal carcinoma patients with high CD16+ cell infiltration was associated with improved overall survival after adjusting for known prognostic factors and this association was independent from CD8+ lymphocyte infiltration and presence of metastases.