CCL3 / MIP-1 alpha Recombinant Rabbit Monoclonal Antibody [PSH19-79] (HA724103)

UNIPROT #

P10855

PROTEIN NAME

CCL3 / MIP-1 alpha

SYNONYMS

C C motif chemokine 3;CCL 3;CCL3;CCL3_HUMAN;Chemokine (C C motif) ligand 3;Chemokine C C motif ligand 3;Chemokine ligand 3;G0/G1 switch regulatory protein 19 1;G0/G1 switch regulatory protein 19-1;G0S19 1;G0S19 1 protein;Heparin binding chemotaxis protein;L2G25B;LD78 alpha;LD78-alpha(4-69);LD78alpha;Macrophage inflammatory protein 1 alpha;Macrophage inflammatory protein 1-alpha;macrophage inflammatory protein 1a;MIP 1 alpha;MIP 1A;MIP-1-alpha;MIP-1-alpha(4-69);MIP1 alpha;MIP1A;PAT 464.1;SCYA 3;SCYA3;SIS alpha;SIS beta;SIS-beta;Small inducible cytokine A3;small inducible cytokine A3 (homologous to mouse Mip-1a);Small-inducible cytokine A3;Tonsillar lymphocyte LD78 alpha protein

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene. CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5. CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.