Calbindin Recombinant Antibody [JF05-01] - Guinea pig IgG2 (Chimeric) (HA601562)

UNIPROT #

P12658

PROTEIN NAME

Calbindin

SYNONYMS

avian-type antibody;CAB27 antibody;CALB 1 antibody;CALB antibody;CALB1 antibody;CALB1_HUMAN antibody;Calbindin 1 28kDa antibody;Calbindin antibody;Calbindin D28 antibody;D 28K antibody;D-28K antibody;D28K antibody;OTTHUMP00000166027 antibody;OTTHUMP00000225441 antibody;RTVL H protein antibody;Vitamin D dependent calcium binding protein antibody;Vitamin D dependent calcium binding protein avian type antibody;Vitamin D-dependent calcium-binding protein antibody

SUBCELLULAR LOCATION

Cytosol, Nucleus.

FUNCTION

Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease.