Calbindin Recombinant Rabbit Monoclonal Antibody (IRS221RB)

UNIPROT #

P12658

PROTEIN NAME

Calbindin

SYNONYMS

avian-type antibody;CAB27 antibody;CALB 1 antibody;CALB antibody;CALB1 antibody;CALB1_HUMAN antibody;Calbindin 1 28kDa antibody;Calbindin antibody;Calbindin D28 antibody;D 28K antibody;D-28K antibody;D28K antibody;OTTHUMP00000166027 antibody;OTTHUMP00000225441 antibody;RTVL H protein antibody;Vitamin D dependent calcium binding protein antibody;Vitamin D dependent calcium binding protein avian type antibody;Vitamin D-dependent calcium-binding protein antibody

SUBCELLULAR LOCATION

Cytosol, Nucleus.

FUNCTION

The family of EF-hand type Ca²⁺-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 α and β, Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14), Calgranulin C and the Parvalbumin family members, including Parvalbumin α and Parvalbumin β (also designated oncomodulin). Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261 amino acid protein with six EF-hand domains, four of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.