BRCC36 Recombinant Rabbit Monoclonal Antibody [PSH05-10] (HA722226)

UNIPROT #

P46736

PROTEIN NAME

BRCC36

SYNONYMS

BRCA1-A complex subunit BRCC36 antibody;BRCA1/BRCA2 containing complex subunit 3 antibody;BRCA1/BRCA2 containing complex subunit 36 antibody;BRCA1/BRCA2-containing complex subunit 3 antibody;BRCA1/BRCA2-containing complex subunit 36 antibody;Brcc3 antibody;BRCC3_HUMAN antibody;BRCC36 antibody;BRISC complex subunit BRCC36 antibody;C6.1A antibody;Chromosome X open reading frame 53 antibody;CXorf53 antibody;Lys-63-specific deubiquitinase BRCC36 antibody;OTTHUMP00000061450 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, cytoskeleton, spindle pole.

FUNCTION

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants. BRCC36, the protein product of the BRCC3 gene, is a deubiquitinating enzyme and a core component of the deubiquitin complex BRCA1-A. BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ). The role of BRCA1-A appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting DNA repair by NHEJ in preference to HR.