Biotin Conjugated Human UMOD Recombinant Rabbit Monoclonal Antibody - Detector [PSH24-70] (HA724466B)

UNIPROT #

P07911

PROTEIN NAME

UMOD

SYNONYMS

ADMCKD2 antibody;FJHN antibody;HNFJ antibody;HNFJ1 antibody;MCKD2 antibody;medullary cystic kidney disease 2 (autosomal dominant) antibody;Tamm Horsfall glycoprotein antibody;Tamm Horsfall urinary glycoprotein antibody;Tamm-Horsfall urinary glycoprotein antibody;THGP antibody;THP antibody;Umod antibody;Urehd1 antibody;urehr4 antibody;UROM_HUMAN antibody;uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody;Uromodulin antibody;Uromodulin, secreted form antibody;Uromucoid antibody

SUBCELLULAR LOCATION

Apical cell membrane, Basolateral cell membrane, Cell projection, cilium membrane.

FUNCTION

Uromodulin (UMOD),Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine. Uromodulin excretion in urine follows proteolytic cleavage of the ectodomain of its glycophosphatidylinositol-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. The excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. The function of THP is not well understood. Studies using THP deficient mice revealed that THP may have a role in regulatory physiology and actually participates in transporter function. A role in bacterial binding and sequestration is suggested by studies showing that Escherichia coli which express MS (mannose-sensitive) pili or fimbriae (also fimbria, from the Latin word for "fringe") can be trapped by Tamm–Horsfall protein via its mannose-containing side chains. THP may also be important in protection from kidney injury by down-regulating inflammation.