Biotin Conjugated Human LIF Recombinant Rabbit Monoclonal Antibody [PSH05-97] (HA722586B)

UNIPROT #

P15018

PROTEIN NAME

Human LIF

SYNONYMS

CDF antibody;Cholinergic Differentiation Factor antibody;D factor antibody;DIA antibody;Differentiation inducing factor antibody;differentiation inhibitory activity antibody;Differentiation stimulating factor antibody;Differentiation-stimulating factor antibody;Emfilermin antibody;Hepatocyte stimulating factor III antibody;HILDA antibody;Human interleukin in DA cells antibody;Leukemia inhibitory factor antibody;LIF antibody;LIF_HUMAN antibody;Melanoma derived LPL inhibitor antibody;Melanoma-derived LPL inhibitor antibody;MLPLI antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.