Biotin Conjugated Human IL-3 Mouse Monoclonal Antibody [PSH0-98] (HA601359B)

UNIPROT #

P08700

PROTEIN NAME

Human IL-3

SYNONYMS

Colony stimulating factor multiple antibody;Hematopoietic growth factor antibody;IL 3 antibody;IL-3 antibody;IL3 antibody;IL3_HUMAN antibody;Interleukin 3 (colony stimulating factor, multiple) antibody;Interleukin 3 antibody;Interleukin-3 antibody;Mast cell growth factor antibody;MCGF antibody;MGC79398 antibody;MGC79399 antibody;Multi CSF antibody;Multilineage colony stimulating factor antibody;Multipotential colony stimulating factor antibody;Multipotential colony-stimulating factor antibody;OTTHUMP00000065963 antibody;P cell stimulating factor antibody;P-cell-stimulating factor antibody

SUBCELLULAR LOCATION

Secreted

FUNCTION

Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.