Biotin Conjugated Human GITR Recombinant Rabbit Monoclonal Antibody [PSH05-64] (HA722593B)

UNIPROT #

Q9Y5U5

PROTEIN NAME

Human GITR

SYNONYMS

Activation inducible TNFR family receptor antibody;Activation-inducible TNFR family receptor antibody;AITR antibody;CD357 antibody;GITR antibody;GITR D antibody;GITR-D antibody;GITRD antibody;Glucocorticoid induced TNFR related protein antibody;glucocorticoid-induced tnf receptor ligand antibody;glucocorticoid-induced tnf receptors ligand antibody;Glucocorticoid-induced TNFR-related protein antibody;TNF receptor superfamily activation inducible protein antibody;TNFRSF 18 antibody;TNFRSF18 antibody;TNR18_HUMAN antibody;Tumor necrosis factor receptor superfamily member 18 antibody;Tumor necrosis factor receptor superfamily member 18 precursor antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.