Biotin Conjugated Human CXCL1/GRO alpha Recombinant Rabbit Monoclonal Antibody [PSH05-95] (HA722587B)

UNIPROT #

P09341

PROTEIN NAME

Human CXCL1/GRO alpha

SYNONYMS

C-X-C motif chemokine 1 antibody;chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antibody;fibroblast secretory protein antibody;FSP antibody;GRO antibody;GRO protein, alpha antibody;GRO-alpha(1-73) antibody;GRO1 antibody;GRO1 oncogene (melanoma growth stimulating activity, alpha) antibody;GRO1 oncogene (melanoma growth-stimulating activity) antibody;GRO1 oncogene antibody;GROa antibody;growth-regulated alpha protein antibody;Keratinocyte-derived chemokine, mouse, homolog of antibody;melanoma growth stimulatory activity alpha antibody;Melanoma growth stimulatory activity antibody;MGSA a antibody;MGSA alpha antibody;MGSA antibody;NAP 3 antibody;Neutrophil-activating protein 3 antibody;SCYB1 antibody;Small inducible cytokine subfamily B, member 1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.